منابع مشابه
ICAM-1: isoforms and phenotypes.
ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses. The function and expression of these isoforms on various cell types a...
متن کاملICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
The interaction of lymphocyte function-associated antigen-1 (LFA-1) with its ligands mediates multiple cell adhesion processes of capital importance during immune responses. We have obtained three anti-ICAM-3 mAbs which recognize two different epitopes (A and B) on the intercellular adhesion molecule-3 (ICAM-3) as demonstrated by sequential immunoprecipitation and cross-competitive mAb-binding ...
متن کاملThe Effects of Resistance Training on VCAM-1, ICAM-1 and CRP in Diabetic Rats
Objective: Many diabetic patients are susceptible to cardiovascular diseases which are known as one of the most important causes of mortality among diabetic patients. The aim of this study was to investigate the effects of eight weeks of resistance training on VCAM-1, ICAM-1 and CRP in diabetic rats. Materials and Methods: In this experimental study, 24 male Sprague- Dawley diabetic rats were ...
متن کاملForce spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2.
Single-molecule measurements of the interaction of leukocyte function-associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM). The force spectra (i.e., unbinding force versus loading rate) of both the LFA-1/ICAM-1 and LFA-1/ICAM-2 interactions were acquired at a loading rate ...
متن کاملLFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.
The role of CD28/B7 and LFA-1/ICAM costimulation in proliferation and Th1/Th2 differentiation of naive CD4+ T cells was addressed using T cells from DO11.10 TCR transgenic mice stimulated by dendritic cells. The blockade of either CD28/B7 or LFA-1/ICAM interactions partially inhibited T cell proliferation. By comparison, blocking CD28/B7 costimulation inhibited IL-4 and IL-5 (Th2 cytokine) prod...
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ژورنال
عنوان ژورنال: Pharmaceutica Acta Helvetiae
سال: 2000
ISSN: 0031-6865
DOI: 10.1016/s0031-6865(99)00056-4